Dr Rahul Bhargava

MBBS, MD, DM (Clinical Haematology)

Principal Director & Chief Hematology at Fortis Hospital

MBBS, MD, DM (Clinical Haematology)

Principal Director & Chief Hematology at Fortis Hospital

Cost of Allogenic Bone Marrow Transplant in India

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Cost of Allogenic Bone Marrow Transplant in India

The cost of an allogenic bone marrow transplant in India ranges from INR 10,00,000 to INR 25,00,000, which is approximately USD 12,000 to USD 30,000 (depending on the exchange rate). The actual cost can vary due to several factors, including:

  • Hospital facility and city
  • Expertise and experience of the medical team
  • The specific type of transplant (whether fully matched or haploidentical)
  • Duration of hospital stay and post-surgery recovery

Compared to many Western countries, where the cost of an allogenic bone marrow transplant can exceed USD 100,000 to USD 300,000, India offers world-class treatment at a fraction of the cost. This makes India a preferred destination for international patients seeking affordable medical care.

Causes Leading to Bone Marrow Transplant

Bone marrow transplants are usually recommended for patients with specific diseases that affect the production of healthy blood cells. The primary causes or conditions that may necessitate an allogenic bone marrow transplant include:

  • Blood cancers (Leukemia, Lymphoma)
  • Bone marrow failure (Aplastic Anemia)
  • Genetic disorders (Thalassemia, Sickle Cell Anemia)
  • Immune system disorders
  • Radiation or chemotherapy-induced marrow damage

Doctors assess the patient’s overall health and disease stage before recommending the procedure.

Symptoms Treated by Allogenic Bone Marrow Transplant

Allogenic bone marrow transplants are often used to treat conditions related to blood or bone marrow disorders. Common symptoms that may indicate the need for this procedure include:

  • Persistent fatigue
  • Frequent infections
  • Easy bruising or bleeding
  • Anemia or low red blood cell count
  • Recurring fevers or night sweats

Doctors recommend transplants for diseases such as leukemia, lymphoma, myelodysplastic syndromes, and aplastic anemia.

Risk Factors Associated with Allogenic Bone Marrow Transplants

While allogenic bone marrow transplants can be life-saving, they come with several risk factors:

  • Graft-versus-host disease (GVHD): The donor’s immune cells may attack the recipient’s tissues.
  • Infections: Reduced immunity can increase susceptibility to infections.
  • Organ damage: Some patients may experience complications affecting the liver, lungs, or heart.
  • Bleeding: Bone marrow recovery may take time, increasing the risk of bleeding and anemia.
  • Infertility: Chemotherapy and radiation can lead to infertility in some patients.

Doctors will closely monitor the patient before and after the procedure to manage these risks.

Bone Marrow Transplant Surgery Procedure

The surgery procedure for an allogenic bone marrow transplant follows several steps:

  1. Pre-transplant Preparation: The patient undergoes chemotherapy or radiation to destroy diseased cells and suppress the immune system.
  2. Donor Matching: A matching donor is selected based on HLA (Human Leukocyte Antigen) typing to reduce rejection risks.
  3. Stem Cell Harvesting: Stem cells are collected from the donor’s bone marrow or blood through apheresis.
  4. Transplantation: The donor’s healthy stem cells are infused into the recipient’s bloodstream through an intravenous (IV) line.
  5. Recovery and Engraftment: The new stem cells travel to the bone marrow, where they begin producing healthy blood cells.

The entire process can take several weeks, and patients are monitored closely for any complications.

Post-Surgery Care and Recovery

After the transplant, post-surgery care is crucial for a successful recovery:

  • Hospital Stay: Patients may need to stay in the hospital for 4 to 6 weeks in a sterile environment to prevent infections.
  • Regular Monitoring: Doctors will conduct frequent blood tests to check for signs of engraftment and monitor organ function.
  • Medications: Patients receive immunosuppressive drugs to prevent GVHD and antibiotics to prevent infections.
  • Lifestyle Adjustments: A strict diet and hygiene routine are necessary to reduce the risk of infection. Avoiding crowded places is essential during the recovery period.

Recovery can take several months, and patients will need regular follow-ups with their healthcare team.

Success Rate of Allogenic Bone Marrow Transplant in India

India has seen significant success in the field of bone marrow transplants. The success rate of allogenic bone marrow transplants in India is approximately 60-80%, depending on factors like:

  • Patient’s age and overall health
  • Disease type and stage
  • Match quality between the donor and recipient
  • Early detection of complications

Experienced medical professionals and state-of-the-art facilities in India contribute to the high success rates of these transplants.

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